2-Chloro-5-iodobenzoic acid is a highly functionalized halogenated aromatic building block widely used in medicinal chemistry. It serves as a key intermediate for the synthesis of modern pharmaceuticals, particularly SGLT2 inhibitors for diabetes treatment.
| CAS Number | 19094-56-5 |
| Chemical Formula | C7H4ClIO2 |
| Molecular Weight | 282.46 g/mol |
| Appearance | White to off-white or light beige crystalline powder |
| Melting Point | 158 – 164 °C |
| Purity | ≥ 98.0% |
| Solubility |
Soluble in methanol, DMSO, and acetone; poorly soluble in water |
| Safety Information |
Irritant (GHS07). Causes skin, eye, and respiratory irritation. Handle with appropriate PPE and adequate ventilation. |
| Packing |
Laboratory packs: 25 g, 100 g, 500 g bottles Industrial packs: 25 Kg fiber drums with PE liners |
| Synonyms | 5-Iodo-2-chlorobenzoic acid |
| Uses |
Primarily used as a critical synthetic intermediate in the production of gliflozin-class drugs such as Empagliflozin. Also widely used as a substrate for palladium-catalyzed cross-coupling reactions to form complex biaryl molecules. |
