5-Bromo-2-chlorobenzoic acid is a halogenated aromatic carboxylic acid widely used as a key building block in pharmaceutical and specialty chemical synthesis. Its dual halogen substitution makes it especially valuable for cross-coupling and advanced medicinal chemistry routes.
| CAS Number | 21739-92-4 |
| Chemical Formula | C7H4BrClO2 |
| Molecular Weight | 235.46 g/mol |
| Appearance | White to off-white or pale yellow crystalline powder |
| Melting Point | 155 – 160 °C |
| Purity | ≥ 98.0% |
| Solubility |
Soluble in methanol, ethanol, and DMSO; poorly soluble in water |
| Safety Information |
Classified as an irritant (GHS07). Causes skin and eye irritation and may cause respiratory irritation. Use standard laboratory PPE and adequate ventilation. |
| Packing |
Laboratory packs: 25 g, 100 g, 500 g bottles Industrial packs: 25 Kg fiber drums with double-layered PE liners |
| Synonyms | 2-Chloro-5-bromobenzoic acid |
| Uses |
Primarily used as a key intermediate in the synthesis of SGLT2 inhibitors such as Empagliflozin and Dapagliflozin for the treatment of Type 2 diabetes. Also widely used as a substrate in palladium-catalyzed cross-coupling reactions. |
