![Acalacbrutinib intermediate 4-[(pyridine-2-yl) amino carbonyl] phenyl boronic acid](https://www.gagangiripharmachem.com/wp-content/uploads/2026/01/Acalacbrutinib-intermediate-4-pyridine-2-yl-amino-carbonyl-phenyl-boronic-acid.jpg)
This compound is an intermediate, or precursor, in the multi-step chemical synthesis of acalabrutinib. Acalabrutinib is a kinase inhibitor used to treat mantle cell lymphoma and chronic lymphocytic leukemia.
| CAS Number | 850568-25-1 |
| Chemical Name | 4-(Pyridin-2-yl)aminocarbonylphenylboronic acid |
| Chemical Formula | C12H11BN2O3 |
| Molecular Weight | 242.04 g/mol |
| SMILES | O=C(C1=CC=C(B(O)O)C=C1)NC2=NC=CC=C2 |
| Melting Point | 124 – 128 °C |
| Density | 1.33 g/cm³ |
| Solubility | Slightly soluble in water (≈ 1.8 g/L at 25 °C) |
| Packing |
Powder form: 25 Kg HEDP bag with 2 inner liners (5-layer protected packaging) |
| Synonyms |
(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic acid, 4-(Pyridin-2-yl-aminocarbonyl)benzeneboronic acid, [4-[(Pyridin-2-yl)carbamoyl]phenyl]boronic acid, 4-(2-Pyridylcarbamoyl)benzeneboronic acid, N-2-Pyridinyl 4-boronobenzamide |
| Uses |
Used as a key pharmaceutical intermediate in the synthesis of anticancer drugs such as Acalabrutinib. As a boronic acid derivative, it is also widely applied in drug discovery, particularly for the development of kinase inhibitors and related therapeutic molecules. |
