3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
The term “Ebrutiniub” appears to be a typo for the drug Ibrutinib, and its intermediate, 3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (CAS No. 330792-70-6), is a chemical used in the synthesis of this medication. Ibrutinib is an oral medication that is used to treat various forms of cancer, such as chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenström’s macroglobulinemia..
| CAS Number | 330792-70-6 |
| Chemical Formula | C16H12N4O |
| Molecular Weight | 276.29 g/mol |
| Appearance | White to off-white or light yellow powder |
| Assay (HPLC) |
Common grade: ≥ 98.0% High grade: ≥ 99.0% |
| Melting Point | Not available (N/A) |
| Boiling Point | 585.3 ± 50.0 °C (predicted) |
| Density | 1.37 ± 0.1 g/cm³ (predicted) |
| Solubility | Slightly soluble in DMSO |
| Packing |
Powder form: 25 Kg HEDP bag with 2 inner liners (5-layer protected packaging) |
| Synonyms |
5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile, Ibrutinib Intermediate, Ibrutinib N-3, Ibrutinib Intermediate 3 / 4, Zanubrutinib Impurity 8, Zanubrutinib Impurity-20 |
| Uses |
Used as a key pharmaceutical intermediate in the synthesis of Ibrutinib and potentially Zanubrutinib. These drugs are Bruton’s tyrosine kinase (BTK) inhibitors used in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). |
