4-Iodoanisole, also known as para-iodoanisole, is a halogenated aromatic ether widely used as a building block in organic synthesis. It is especially valued for introducing methoxyphenyl groups through palladium-catalyzed coupling reactions.
| CAS Number | 696-62-8 |
| Chemical Formula | C7H7IO |
| Molecular Weight | 234.03 g/mol |
| Appearance |
White to light yellow or brown crystalline powder, chunks, or needles |
| Melting Point | 50 – 53 °C |
| Purity | ≥ 98.0% or ≥ 99.0% |
| Solubility |
Soluble in ethanol, ether, chloroform, and methanol; insoluble in water |
| Safety Information |
Classified as an Irritant (GHS07) and Environmental Hazard (GHS09). Causes skin, eye, and respiratory irritation and is toxic to aquatic life. Handle with full PPE in a well-ventilated area. |
| Packing |
Laboratory packs: 25 g, 100 g, 500 g amber glass or plastic bottles Industrial packs: 25 Kg to 50 Kg HDPE or fiber drums with light-resistant liners |
| Synonyms |
p-Iodoanisole, 4-Methoxyiodobenzene, 1-Iodo-4-methoxybenzene |
| Uses |
Primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and liquid crystals. It is widely employed in palladium-catalyzed cross-coupling reactions such as Suzuki and Buchwald–Hartwig couplings. |
